Men’s College Basketball Picks Against the Spread for February 22, 2025

Rolling Out of Bed with College Basketball Picks

Matty D here from CollegeBasketballItest.com, and I’m back again with another round of early college basketball picks. This approach worked well for me last week, and I’m looking to keep the momentum going. Let’s dive into some suspect spreads and intriguing matchups from today’s slate.

Tennessee vs. Texas A&M

Texas A&M is favored by 1.5 points in this matchup against Tennessee. This might come as a surprise considering I’ve been high on Texas A&M as a potential championship contender at 40 or 50 to 1 odds. However, despite my faith in the Aggies, I think Tennessee is the better team. The Vols haven’t played to their full potential over the last month, but I see this as a good spot for them. I’m taking Tennessee and the 1.5 points here.

Oregon vs. Wisconsin

Oregon is an 8.5-point underdog against Wisconsin. The Badgers have been playing strong basketball recently, but Oregon is fighting for a tournament spot, and 8.5 points is a lot to be giving up. I like Oregon to cover in this one.

Florida State vs. Louisville

Louisville is favored by 13.5 points against Florida State. The Seminoles have struggled lately, and with Louisville’s up-tempo style of play under head coach Pat Kelsey, I think they have the potential to cover the spread. They’re a top-25 team, and with their current momentum, they could handle this one convincingly.

Texas Tech vs. West Virginia

West Virginia is laying 11.5 points against Texas Tech. This is a tough game to call, especially with West Virginia missing one of its key players, Tucker DeVries, whose father, Darian DeVries, is the team’s head coach. If I had to pick, I’d lean toward West Virginia, but this might be a game to avoid altogether.

Iowa State vs. Houston

One of the marquee matchups of the day features Iowa State taking on Houston. Both teams are elite defensively and could make deep tournament runs. Surprisingly, Iowa State is getting 11.5 points. In what should be a low-scoring defensive battle, that’s a big number to be receiving. I like Iowa State to cover, especially since they might be looking for a bounce-back performance after a disappointing showing recently.

Georgia vs. Auburn

Auburn is a 16.5-point favorite against Georgia. The Bulldogs have been a tough out for some SEC teams this season, making this a tricky game. I’m staying away from this one because I don’t want to be sweating in the final moments to see if Auburn covers or not.

Clemson vs. SMU

SMU put on an offensive clinic against Notre Dame recently, so I’m surprised to see them as an underdog at home against Clemson. With SMU getting 1.5 points, I’m taking them in this spot.

Oklahoma State vs. Kansas

Kansas is giving 14.5 points to Oklahoma State, and I don’t think they should be laying that many points to anyone right now. The Jayhawks have been inconsistent, especially during their trip out west against Utah and BYU. I’ll probably stay away from this game entirely, but if I had to pick, I’d take Oklahoma State with the points.

Florida vs. LSU

Florida is favored by 10.5 points against LSU. The Tigers are one of the few SEC teams unlikely to make the tournament, while Florida is in contention for a No. 1 seed. I believe Florida can cover the spread here, as they have much more at stake.

Kentucky vs. Alabama

This game was an instant classic when these two teams faced off in Lexington on MLK weekend. Now, Kentucky is a 10.5-point underdog as they travel to Alabama. That spread seems a bit high, but I’ll be holding off on making a final call until I see more developments.

St. Mary’s Visits Gonzaga as a 6 Point Favorite

St. Mary’s and Gonzaga battled things out about a month ago with St. Mary’s hosting as a slight underdog. In a bizarre display of many missed free throws, the Gaels survived an ugly contest. I just think Gonzaga is overdue for a good showing here at home and a quality win to solidify a tournament berth as a lower seed than we’re used to seeing the Bulldogs. My guess is that they’ll finish the season as a 9 or 10 seed.

St. Mary’s has a son of a former NBA star on its roster. Can you name him?
👶Click here for the list of sons of NBA players in the 2025 Men’s College Basketball Season👶

College Basketball Against the Spread Picks – Closing Thought

That wraps up my early thoughts as I roll out of bed, checking for suspect spreads. Be sure to check out my website, CollegeBasketballItest.com, as well as my YouTube and Twitter for more picks and insights. Let me know what you’re seeing today, and enjoy the action!