Looking for smart betting picks for Thursday’s Sweet 16 matchups? This article breaks down four key NCAA Tournament games, with against-the-spread predictions for Michigan vs. Auburn, Michigan State vs. Ole Miss, BYU vs. Alabama, and Arizona vs. Duke. See which underdogs have value and which favorites are poised to cover based on matchups that pass the eye test.

It’s funny how reunions of both friends and foes are a constant theme of the college basketball tournament. Caleb Love will, again, be battling with his former in-conference rival, Duke. As you know, Love played for years at UNC where there were some classic clashes with the Blue Devils.
Click here to read 6 more trends fixed as annual traditions during March Madness
Michigan +8.5 vs. Auburn College Basketball Prediction, Pick
Michigan enters this Sweet 16 matchup with one of the biggest frontcourts still standing. Auburn might be the higher seed, but the Wolverines can lean on their size and physicality to dictate the terms of this game. The rebounding edge is where this could tilt. Second-chance points, long possessions—those all benefit Michigan’s style of play. Auburn will try to run, but Michigan has enough discipline and toughness to weather that storm. It’s a tall task to win outright, but getting eight-and-a-half points here looks appealing.

Michigan State -3.5 vs. Ole Miss College Basketball Prediction, Pick
It’s March. And that means one thing: Tom Izzo. His teams tend to tighten up their execution just when other squads start fraying. This version of the Spartans is classic Izzo—experienced guards, versatile forwards, and an edge in physical matchups like this one. Ole Miss has impressed with some big wins to get here, but Michigan State’s defense and discipline should win out in the late possessions. Laying 3.5 with Izzo in March? That always looks good to the eye.
BYU +4.5 vs. Alabama College Basketball Prediction, Pick
This is the most intriguing game of the night for me. Alabama is deep and dangerous, no doubt. But BYU is one of the few teams in the country that can go possession-for-possession with them and keep up the scoring. The Cougars have sharpshooters at every position and play with a pace and confidence that won’t shrink against the Crimson Tide’s press and length. In any 5-on-5 set, BYU can match Alabama bucket for bucket. I wouldn’t be surprised to see the Cougars win this one outright, and grabbing 4.5 points in a shootout like this looks like a lock.
Arizona +8.5 vs. Duke College Basketball Prediction, Pick
This is where things get tricky. Arizona has the physical tools and offensive firepower to give Duke problems—especially in transition. The Wildcats move the ball well and know how to punish mismatches. But let’s be real: Duke is playing with an NBA showcase right now. They’ve got four, maybe five pros on the floor, and they’re all playing like it’s draft week. Arizona should keep this tight with their own versatility, but I’m not sold on them pulling it out late. Still, 8.5 points feels like too many in a game with this much top-end talent. Arizona to cover looks like a confident lean, even if the Blue Devils escape with the W.










